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近年来,有机小分子催化的串联反应已成为众多有机化学家们的研究热点,是合成手性化合物的有效方法。在众多不同催化体系中,手性叔胺催化的不对称串联反应得到了空前的发展。氧化吲哚螺环骨架是很多具有药理活性分子普遍存在的结构形式,含有该骨架的化合物是众多药物及有机化学家们的目标产物,不对称催化串联反应是合成氧化吲哚螺环化合物的重要理论基础和有力学术支撑。本文对近四年手性叔胺催化的不对称串联反应构建氧化吲哚螺环化合物的研究进行介绍。
In recent years, the series reaction catalyzed by small organic molecules has become a research focus of many organic chemists and is an effective method for synthesizing chiral compounds. In many different catalytic systems, chiral tertiary amine catalyzed asymmetric tandem reactions have been an unprecedented development. The oxidized indole spirocyclic skeleton is a ubiquitous structural form of many pharmacologically active molecules. Compounds containing this skeleton are the target products of many pharmaceutical and organic chemists. Asymmetric catalytic tandem reactions are important for the synthesis of oxidized indole spiro compounds Theoretical basis and strong academic support. In this paper, the recent four years of chiral tertiary amine catalyzed asymmetric tandem reaction of oxidized indole spiro compounds introduced.