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目的:研究CYP2E1基因1019位点多态性与肺癌易感性的关系。方法:检索数据库,按纳入标准进行筛选,对纳入文献用Review Manager 4.2软件进行Meta分析,得到合并OR值(95%CI),并进行一致性检验及发表偏倚检验。结果:共纳入文献11篇,累积病例1 278例,对照1 568例,与野生纯合基因型c1c1相比较,突变杂合基因型c1c2、突变纯合基因型c2c2和(c1c2+c2c2)合并的OR值分别为0.74(0.63,0.87)、0.90(0.63,1.28)和0.73(0.63,0.86)。结论:CYP2E1基因1019位点c2突变子是肺癌的保护因素。
Objective: To investigate the relationship between CYP2E1 gene polymorphism at 1019 locus and lung cancer susceptibility. Methods: The database was searched and screened according to inclusion criteria. Meta-analysis was performed on the included documents with Review Manager 4.2 software to get the combined OR (95% CI), and the consistency test and publication bias test were performed. Results: A total of 11 articles were included, including 1 278 cumulative cases and 1 568 controls. Compared with the wild homozygous genotype c1c1, the mutant heterozygous genotype c1c2, the mutant homozygous genotype c2c2 and the (c1c2 + c2c2) OR values were 0.74 (0.63, 0.87), 0.90 (0.63, 1.28) and 0.73 (0.63, 0.86), respectively. Conclusion: The c2 mutation of CYP2E1 gene at position 1019 is a protective factor for lung cancer.