测定了替硝唑对临床分离的１４８株厌氧菌和２株标准株的ＭＩＣ，确定替硝唑对革兰氏阴性厌氧菌活性最强，其ＭＩＣ为０．０６２～１ｍｇ／Ｌ，它们对梭菌的ＭＩＣ为０．２５～０．５ｍｇ／Ｌ，对革兰氏阳性无芽孢厌氧杆菌，除了真杆菌ＭＩＣ为４ｍｇ／Ｌ外，抗菌活性较低，其ＭＩＣ为大于６４ｍｇ／Ｌ，对厌氧球菌也有相当的活性，其ＭＩＣ为０．２５～１．０ｍｇ／Ｌ。 The MICs of 148 anaerobic and 2 standard isolates isolated from clinical isolates of tinidazole were determined. The results showed that tinidazole was the most active against Gram-negative anaerobic bacteria with MIC of 0.062 ~ 1 mg / L MIC for Clostridium was 0.25-0.5 mg / L. For Gram-positive spore-forming anaerobic bacilli, except for the eubacterium MIC being 4 mg / L, the antibacterial activity was lower and its MIC was more than 64 mg / L. Anaerobic bacteria also have considerable activity, the MIC was 0.25 ~ 1.0mg / L.