45只体重250—300克的豚鼠用邻苯二甲酸酐—牛血清白蛋白注射免疫,15只正常豚鼠作对照。吸入邻苯二甲酸酐—人血清白蛋白后,实验组有40只动物(88%)出现哮喘发作。用其中4只哮喘动物血清给正常未致敏豚鼠做被动转移试验,亦同样诱发致哮喘。哮喘动物的病理学观察表现为支气管壁的嗜酸性粒细胞浸润,管腔中有由嗜酸性粒细胞、粘液及少许脱落的上皮细胞组成的栓塞,肺泡腔扩大,肺泡壁变薄等一系列符合一般变应性哮喘的形态学改变。 Forty-five guinea pigs weighing 250-300 g were immunized with phthalic anhydride-bovine serum albumin and 15 normal guinea pigs were used as controls. After inhaling phthalic anhydride-human serum albumin, 40 animals (88%) in the experimental group developed asthma attacks. Four of these asthma animal serum to normal non-sensitized guinea pigs do passive transfer test, also induced asthma. Pathological observation of asthmatic animals manifested as eosinophil infiltration of the bronchial wall, the lumen with eosinophils, mucus and a little off epithelial cells consisting of embolism, alveolar expansion, thinning of the alveolar wall and a series of compliance Morphological changes in general allergic asthma.