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目的研究雷公藤多苷片对中老年慢性肾炎患者蛋白尿的治疗作用及其与C-反应蛋白(CRP)的关系。方法 60例中老年慢性肾炎患者随机分为雷公藤多苷片组和对照组各30例,观察24h尿蛋白定量、血浆CRP、肝肾功能及血常规的变化。结果治疗3月后,雷公藤组的24h尿蛋白定量、CRP明显低于对照组(P<0.05);肝肾功能与对照组比较无显著差异(P>0.05)。结论雷公藤多苷片能减轻中老年慢性肾炎患者尿蛋白排出,该作用可能通过降低炎症因子CRP的抗炎作用实现。
Objective To investigate the therapeutic effect of tripterygium wilfordii glycosides tablet on proteinuria in elderly patients with chronic nephritis and its relationship with C-reactive protein (CRP). Methods Sixty middle-aged and elderly patients with chronic nephritis were randomly divided into tripterygium glycosides group and control group, with 30 cases each. The 24-hour urinary protein, plasma CRP, liver and kidney function and blood routine were observed. Results After 3 months treatment, the urinary protein excretion and CRP in Tripterygium wilfordii group were significantly lower than those in the control group (P <0.05). There was no significant difference in liver and kidney function between the two groups (P> 0.05). Conclusion Tripterygium glycosides tablet can relieve urinary protein excretion in patients with chronic nephritis in middle-aged and elderly patients. This effect may be achieved by reducing the anti-inflammatory effect of CRP.