论文部分内容阅读
目的 :探讨增殖细胞核抗原 (PCNA)表达与喉肿瘤颈部淋巴结转移 (PN+)行为的关系。方法 :应用免疫组化方法检测 73例晚期喉癌中 PCNA表达、病理学方法检查颈部阳性淋巴结数。结果 :PCNA表达与淋巴结转移的数目及范围有相关性 ,PN3 与 PN1～ 2 、PN0 之间有显著性差异 ;在隐性淋巴结转移与临床颈淋巴结阴性(CNo)之间无显著性差异。结论 :PCNA表达可能有助于预测淋巴结转移数目及转移的范围 ,对隐性淋巴结转移预测没有帮助 ,对 PCNA高表达的患者应常规行颈部淋巴结探查。
Objective: To investigate the relationship between the expression of proliferating cell nuclear antigen (PCNA) and the behavior of lymph node metastasis (PN +) in laryngeal neoplasms. Methods: The expression of PCNA in 73 cases of advanced laryngeal carcinoma was detected by immunohistochemistry. The number of cervical lymph nodes was examined by pathology. Results: There was a correlation between the expression of PCNA and the number and extent of lymph node metastasis. There was a significant difference between PN3 and PN1 ~ 2 and PN0. There was no significant difference between CNL and latent lymph node metastasis. CONCLUSION: The expression of PCNA may be helpful in predicting the number of lymph node metastasis and the range of metastasis. It is not helpful for the prediction of latent lymph node metastasis. The cervical lymph node dissection should be routinely performed in patients with high expression of PCNA.