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目的通过成本-效益分析,探讨建立保护中国人群健康的合理的食品中黄曲霉毒素限量标准。方法利用传统数学模型方法和暴露限值(MOE)方法评估花生及其制品、玉米、大米中不同膳食总黄曲霉毒素和黄曲霉毒素B1限量标准下的健康影响,同时计算各限量水平下的食品损失。结果花生及其制品、玉米中总黄曲霉毒素、黄曲霉毒素B1限量水平的改变对减少我国人群肝癌患病数的作用没有显著差别,但不同的限量水平却可导致显著不同的食品损失。大米中总黄曲霉毒素、黄曲霉毒素B1限量水平的改变对减少我国人群肝癌患病数的作用以及导致的食品损失有较显著的影响。结论花生及其制品中总黄曲霉毒素20μg/kg、黄曲霉毒素B1 15μg/kg;玉米中总黄曲霉毒素20μg/kg、黄曲霉毒素B1 15μg/kg;大米中总黄曲霉毒素10μg/kg、黄曲霉毒素B1 5μg/kg或10μg/kg的限量标准比较合适。
Objective To explore the limit of aflatoxin in food which is reasonable to protect the health of Chinese people through cost-benefit analysis. Methods The traditional mathematical model method and the limit of exposure (MOE) method were used to evaluate the health effects of different dietary aflatoxins and aflatoxins B1 in peanut and their products, corn and rice, and the foods under the limited levels loss. Results The change of the limit of total aflatoxins and aflatoxin B1 in peanut and its products, corn had no significant difference in reducing the number of HCC in our population, but different limited levels could lead to significantly different food losses. The change of the total aflatoxins and aflatoxin B1 in rice has a significant impact on reducing the number of liver cancer in our population and the food loss caused. Conclusions Total aflatoxin 20μg / kg, aflatoxin B1 15μg / kg in peanut and its products; Total aflatoxin 20μg / kg in corn, aflatoxin B1 15μg / kg; Total aflatoxin in rice 10μg / kg, Aflatoxin B1 5μg / kg or 10μg / kg of the more appropriate standard.