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应用二乙氨基葡聚糖A-50小柱层析法,从血清分离出一种新GGT同工酶,名之为P-GGT。正常人活力为0.73土0.05u/L,80％以上的胰癌(原发性和转移性)、十二指肠乳头癌病人P-GGT大于10u/L,而在肝胆疾病、慢性胰腺炎时小于5u/L。胰癌、十二指肠乳头癌病人接受根治手术后其活力降至0或极低水平。测定从手术病人取得的胰、总胆管、十二指肠、肝等组织匀浆中P-GGT,除胰组织(1990～4808u/kg湿重)外,余均含量甚微,提示血清中P-GGT来自胰腺。本组资料表明测定血清中P-GGT活力对胰腺癌诊断有一定价值。
A new GGT isoenzyme, named P-GGT, was isolated from serum using diethylaminodextran A-50 column chromatography. Normal person’s vitality is 0.73 ± 0.05u/L, more than 80% of pancreatic cancer (primary and metastatic), and P-GGT of duodenal papillary carcinoma is greater than 10u/L, while in hepatobiliary disease and chronic pancreatitis Less than 5u/L. The patients with pancreatic cancer and duodenal papillary cancer had their vitality reduced to 0 or very low levels after undergoing radical surgery. The P-GGT in the pancreas, common bile duct, duodenum, liver and other tissue homogenates obtained from the surgical patient was measured. Except pancreatic tissues (1990-4808 u/kg wet weight), the content of the remainder was very small, suggesting that serum P -GGT comes from the pancreas. This group of data shows that the determination of serum P-GGT activity has a certain value for the diagnosis of pancreatic cancer.