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目的:测定稳定型冠心病患者支架植入术(percutanous coronary intervention,PCI)前血浆IIA分泌型磷脂酶A2(group IIAsecretory phospholipase A2,ⅡA-sPLA2)的水平,以探讨该酶与冠脉支架术后再狭窄的可能关系。方法:稳定型冠心病行PCI患者63例,非冠心病患者39例,健康正常对照组42例,分别取外周静脉血测定血浆ⅡA-sPLA2酶浓度。PCI患者6个月后复查造影。结果:PCI患者术前该酶浓度显著高于正常对照组(P<0.05),支架内再狭窄率34.9%,再狭窄(restenosis,RS)患者支架术前该酶水平与无再狭窄患者该酶水平无统计学差异(P>0.05)。结论:PCI患者术前血浆ⅡA-sPLA2酶浓度显著高于正常对照组,但可能与支架术后再狭窄无关。
Objective: To determine the level of plasma group IIA secretory phospholipase A2 (ⅡA-sPLA2) in patients with stable coronary heart disease before percutanous coronary intervention (PCI) The possible relationship of restenosis. Methods: Sixty-three patients with stable coronary artery disease undergoing PCI, 39 patients with non-coronary heart disease and 42 healthy controls were enrolled in this study. Peripheral venous blood was collected to determine the concentration of plasma IIA-sPLA2. PCI patients 6 months after the review of contrast. Results: The preoperative concentration of the enzyme in PCI patients was significantly higher than that in the normal control group (P <0.05). The rate of in-stent restenosis was 34.9%. The level of enzyme before restenosis (RS) No significant difference (P> 0.05). Conclusions: Preoperative plasma concentrations of IIA-sPLA2 in patients with PCI are significantly higher than those in the normal controls, but may not be related to restenosis after PCI.