在幽门螺杆菌(HP)的感染和致病过程中,它所产生的过氧化氢酶发挥着重要作用。本文针对过氧化氢酶作为一种HP疫苗的可能性及效能进行了研究和探讨,报告了纯化天然和重组过氧化氢酶在小鼠感染动物模型中诱导保护性免疫的情况。结果显示:利用来源于HP的过氧化氢酶和佐剂霍乱毒素(CT)预先免疫猫胃螺杆菌(HF)感染小鼠动物模型,可以保护80%(8/10)的小鼠免于HF的再次感染;利用HP过氧化氢酶和CT的重组体预先免疫HP悉尼株感染的小 Catalase produced by it plays an important role in the infection and pathogenesis of Helicobacter pylori (HP). In this paper, the possibility and potency of catalase as an HP vaccine were studied and discussed, and the results showed that purified natural and recombinant catalase induced protective immunity in animal models of infection in mice. The results showed that 80% (8/10) of the mice were protected from HF by pre-immunizing the animal model of mouse infected with HF with catalase derived from HP and adjuvant cholera toxin (CT) Re-infection; pre-immunization of HP Sydney strains infected with a recombinant of HP catalase and CT