阿霉素(Doxorubicin),又名14-羟基柔红霉素,是蒽环类抗肿瘤抗生素,临床上广泛用于恶性实体瘤及血液系统恶性肿瘤的治疗中。但临床上往往需要较大的剂量才会有较好的效果,但大剂量蒽环类较为明显的副作用是心脏毒性,因此限制了其在临床的进一步使用[1]。其心脏毒性常常表现为导致患者心律失常、发生低血压及多种模式的心电图异常,如ST- Doxorubicin, also known as 14-hydroxy daunorubicin, is an anthracycline antitumor antibiotic widely used clinically in the treatment of malignant solid tumors and hematological malignancies. However, clinical trials often require larger doses to achieve better results. However, the more obvious side effects of high-dose anthracyclines are cardiotoxicity, which limits their further clinical use [1]. Cardiac toxicity is often manifested in patients with arrhythmias, hypotension and various patterns of ECG abnormalities such as ST-