论文部分内容阅读
目的评估2岁幼儿尿中双酚A(bisphenol A,BPA)水平和每日摄入量及其影响因素,为进一步研究BPA对幼儿健康影响提供基础数据。方法选取某县365名幼儿,由其父母完成问卷调查并协助幼儿采集尿样,测定尿中BPA含量,估算每日摄入量及分析影响因素。结果 BPA检出率为72.05%,可检出浓度范围为0.20~106.38μg/L,肌酐未校正和校正后中位值分别为0.95μg/L和2.96μg/g。每日摄入量按肌酐估算最大值为4.596μg/kg bw/24h,低于欧盟食品安全机构(European Food Safety Authority,EFSA)提出的BPA每日允许摄入量(tolerable daily intake,TDI)。统计分析结果显示不同性别幼儿BPA水平相似,而不同居住地间BPA水平差异有统计学意义(P<0.05)。结论该地区2岁幼儿普遍暴露于BPA,暴露水平低于EFSA提出的TDI。
Objective To evaluate the urinary bisphenol A (BPA) level, daily intake and its influencing factors in 2-year-old infants, and to provide basic data for further study of the effects of BPA on the health of infants. Methods A total of 365 young children in a county were selected. Their parents completed a questionnaire survey and assisted young children to collect urine samples. The urinary BPA content, estimated daily intake and influencing factors were analyzed. Results The detection rate of BPA was 72.05%. The detectable concentration ranged from 0.20 to 106.38μg / L. The uncorrected and corrected median creatinine levels were 0.95μg / L and 2.96μg / g, respectively. The daily intake, estimated as creatinine maximum, was 4.596 μg / kg bw / 24h, lower than the BPA tolerable daily intake (TDI) proposed by the European Food Safety Authority (EFSA). Statistical analysis showed that BPA levels in different sexes were similar, but BPA levels in different places were significantly different (P <0.05). Conclusions The 2-year-old infant in this area is generally exposed to BPA and the exposure level is lower than the TDI proposed by EFSA.