Access to Stereodefined Multifunctionalized β,γ-Unsaturated Ketones via Chemo-, Regio-and Diastereos

来源 :中国化学(英文版) | 被引量 : 0次 | 上传用户:PeNgxionglifanG2
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Stereodefined β,γ-unsaturated carbonyl compounds are important yet synthetically challenging units in natural products and drugs.Disclosed herein is a mild,rapid copper-catalyzed diborylation reaction of cross-conjugated enynones as a step-economic and modularapproach to stereodefined multifunctionalized β,γ-unsaturated ketones by fine control of chemo-,regio-,Z/E and diastereoselectivity.The substrate scope was examined and a possible catalytic cycle was proposed to explain the multifaceted selectivity.
其他文献
学好用好百年党史,必须树立正确党史观,必须以马克思主义的立场观点方法观察、研究、总结党的历史。习近平在党史学习教育动员大会上强调:“唯物史观是我们共产党人认识把握历史的根本方法”;“既不能因为成就而回避失误和曲折,也不能因为探索中的失误和曲折而否定成就”;“要坚持以我们党关于历史问题的两个决议和党中央有关精神为依据”;“准确把握党的历史发展的主题主线、主流本质”;“要旗帜鲜明反对历史虚无主义”等。深刻理解这些重要论述,对我们在新时代树立正确党史观,反对和抵制历史虚无主义,具有重要的指导
“马保国事件”消解了武术网络媒介形象,表现为荒诞式的话语呈现、断裂化的媒介记忆、消遣式的网民参与,主因是基于视觉媒介的武术欣赏结构变化、媒介奇观效应下的围观扩散、权威话语缺席下的情感消费。在武术与网络的交互关系中,媒介导致武术形象多维消解,集体参与加速武术形象崩解,武术符号形象与现实发展脱节。遏止武术网络形象崩解并重塑积极形象,需利用媒介搭建武术认同基础,推动武术形象正常化发展,多维度强化武术教育。
The OCF3 group has good metabolic stability,suitable lipophilicity and special electrical properties,which can modify the properties of drugs and material molec
Chiral phosphorus ligands have played a crucial role for the recent advances in asymmetric catalysis.This review summarizes chiral phosphorus ligands developed from the Laboratory of Professor Xumu Zhang in the latest 25 years.A number of iconic phosphoru
Persistent luminescence materials(PLMs)are a class of unique luminescent materials that can remain luminescent for a few milliseconds to days without constant excitation.By virtue of the super long decay time,PLMs have been extensively explored in biosens
在《道德经》英译中采用何种翻译策略以及如何操作,将直接决定取得何种语境效果。关联理论提出的四种语境效果——语境暗含、加强、矛盾、削弱,可以有效涵盖复杂的人类交际和充分阐释《道德经》英译行为、过程和结果。在《道德经》英译中采用三个英译策略——归化策略、异化策略、妥协策略,旨在使《道德经》英译文在英语读者身上取得语境暗含和加强这两种正面语境效果。在《道德经》英译中,三个英译策略的具体运用层面是不同的:归化策略始终针对目的语形式表征,异化策略始终针对老子思想内容本色表征,妥协策略则是对原文某些局部措辞或结构进行
中国古代有“辩者”之称,无“名学”之名.传统知识分类体系有“名家”之位,无“名学家”之说.“名家”如何在近代学科分类中演变为“名学”和“名学家”?随着晚清分科体系的
Main observation and conclusion The enantioselective hydrogenation of endocyclic enones has been a historical problem for homogeneous catalysis.We herein report an efficient method to reduce endocyclic enones with molecular hydrogen.Catalyzed by a rhodium
High throughput screening towards chemical libraries is the primary way to discover lead compounds in developing innovative drugs,especially new molecular entit
Stereoselective isomerization of α-alkyl styrenes is accomplished using a new iron catalyst supported by phosphine-pyridine-oxazoline (PPO) ligand.The protocol