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在隔离灌流的大鼠主动脉弓－主动脉神经标本上，观察了心房肽Ⅲ（ａｔｒｉｏｐｅｐｔｉｎⅢ，ＡＰⅢ）对主动脉弓压力感受器活动的影响。主动脉弓内压保持１３．３ｋＰａ条件下向灌流液中加入ＡＰⅢ（２．０μｇ／ｍｌ）后，主动脉神经传入放电较对照值增加６４±２７％（Ｐ＜０．００１）；升降灌流压时，主动脉神经传入放电随之增减，饱和压（ＳＰ）由２２．５±０．５降至２１．３±０．５ｋＰａ（Ｐ＜０．０５），工作范围（ＯＲ）由１２．１±０．４降至１０．６±０．４ｋＰａ（Ｐ＜０．０５），阈压（ＴＰ）无明显变化；压力感受器机能曲线向左上方移位，曲线的最大积分值（ＰＩＶ）由５０８±６６％增至７３０±５２％（Ｐ＜０．０５），曲线最大斜率（ＰＳ）由５５．６±７．５增至９３．２±６．８％·ｋＰａ－１（Ｐ＜０．０５）；冲洗掉ＡＰⅢ后，主动脉神经传入放电基本恢复至对照水平．主动脉弓内压保持在１３．３ｋＰａ条件下，向灌流液中加入硝普钠（ＮＰ，１．０μｇ／ｍｌ），主动脉神经传入放电虽有所减少，但无统计学意义（Ｐ＞０．０５）；升降灌流压时，ＴＰ，ＳＰ，ＯＲ均无明显变化，对压力感受器机能曲线及ＰＳ也无显著影响，而ＰＩＶ由６６７±７８降至５０２±７４％（Ｐ＜?
The effects of atriopeptin Ⅲ (APⅢ) on the activity of aortic arch baroreceptor were observed on isolated aortic arch-aortic nerve grafts from isolated perfused rats. After APⅢ (2.0μg / ml) was infused into the perfusate under aortic pressure of 13.3kPa, the afferent aorta discharge increased by 64 ± 27% (P <0.001) compared with the control value; , The afferent discharge of aortic nerve increased or decreased, the saturation pressure (SP) decreased from 22.5 ± 0.5 to 21.3 ± 0.5kPa (P <0.05), and the working range (OR) decreased from 12. 1 ± 0.4 to 10.6 ± 0.4kPa (P <0.05), and the threshold pressure (TP) did not change significantly. The baroreceptor function curve shifted to the upper left and the maximum integrated value (PIV) 508 ± 66% to 730 ± 52% (P <0.05), and the maximum slope (PS) increased from 55.6 ± 7.5 to 93.2 ± 6.8% · kPa-1 (P <0) .05). After APⅢ was washed away, the afferent aortic nerve was discharged to the control level. Aortic arch internal pressure maintained at 13.3kPa conditions, adding sodium nitroprusside (NP, 1.0μg / ml) to the perfusion fluid, despite a decrease in aortic nerve afferent discharge, but no statistically significant (P> 0. 0.05). There was no significant change in TP, SP and OR at the time of ascending and descending perfusion pressure, and no significant effect on baroreflex function curve and PS, while PIV decreased from 667 ± 78 to 502 ± 74% (P <