文章利用多种色谱技术(包括大孔吸附树脂柱色谱、反相柱色谱及制备型高效液相色谱)对瓜蒌皮水溶性部位的化学成分进行了系统的研究,得到9种化合物,利用紫外光谱、质谱及核磁共振波谱对化合物的结构进行了鉴定,分别为胞嘧啶(1)、尿嘧啶(2)、次黄嘌呤(3)、鸟嘌呤(4)、黄嘌呤(5)、腺嘌呤(6)、鸟嘌呤核苷(7)、6-异次黄嘌呤核苷(8)及腺嘌呤核苷(9),其中化合物1、3、4、5为首次从该植物中得到。 In this paper, the chemical constituents of water-soluble parts of melon skin were systematically studied by a variety of chromatographic techniques (including macroporous resin column chromatography, reversed phase column chromatography and preparative high performance liquid chromatography). Nine compounds were obtained, The structures of the compounds were identified by UV-Vis, MS, 1H-NMR, 1H NMR, (6), guanosine (7), 6-isoxadenosine (8) and adenosine (9). Compounds 1, 3, 4 and 5 were obtained from this plant for the first time.