作者报导一个家族5个成员患原发肥大性骨关关节(PHO)。例1,11岁女孩,X线显示双手远侧指骨对称性呈杵状且发育不良,四肢长管状骨小梁增粗,皮质变薄伴骨膜新生骨。下肢骨干和远侧干骺端增大;双股骨内弯。双胫、腓骨骨干也有骨膜新生骨。远侧趾骨杵状及发育不良。蹠骨及跗骨皆琉松。例2,4岁女孩,手、足远端增大及囟门延迟闭合。X线显示双手远端指骨呈对称性杵状及发育不全。手骨发育如2岁。长骨骨小梁粗糙及皮质变薄。双胫、腓骨骨干增粗伴骨膜新生骨。足变化与手相似。例3,10个月女孩,手、足远侧部增 The authors report that a family of five members had primary hypertrophic osteoarthritis (PHO). Case 1, 11-year-old girl, X-ray showed bilateral phalanx phalanx symmetry and clubbing and stunted limbs tracheal thickening of the trabecular, cortical thinning with new periosteal bone. Lower limbs and distal metaphysis increased; double femoral curve. Bilateral tibial, fibular bone also has periosteal new bone. Distal toe clubbing and dysplasia. Metatarsus and stapes are all pine. Example 2, 4-year-old girl, hands, feet increased distal and fontanelle delayed closure. X-ray shows both hands distal phalanges symmetrical clubbing and hypoplasia. Hand bones such as 2 years old. Long bone trabeculae and cortical thinning. Two tibia, fibular bone thickening with periosteal new bone. Foot changes similar to the hand. Example 3, 10-month girl, hand, foot distal part increased