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采用抗补体活性导向分离法从中药鸭跖草中分离鉴定了24个化合物, 活性测试结果显示6个化合物对补体系统的经典途径和旁路途径显示出不同程度的抑制作用 (CH500.12-1.44 mM, AP500.28-7.05 mM)。作用靶点研究显示喹诺酸作用于补体系统的C1q, C2, C3, C4, C5 和 C9组分; β-谷甾醇作用于C3 和 C4组分; (+)-儿茶素-3-O-β-D-(2-肉桂酰基)-葡萄糖苷、对甲基苯酚和6-甲氧基-3-甲基-1,2,4-苯三酚均作用于C1q, C2, C3, C5 和C9组分。
Twenty-four compounds were isolated and identified from Commelina communis using anti-complement activity-directed isolation method. The results of the activity test showed that six compounds showed different degrees of inhibition on the complement pathway and the classical pathway (CH500.12-1.44 mM, AP500.28-7.05 mM). Targeted studies have shown that quinolinic acid acts on the Clq, C2, C3, C4, C5 and C9 components of the complement system; [beta] -sitosterol acts on the C3 and C4 components; (+) - catechin- -β-D- (2-cinnamoyl) -glucoside, p-methylphenol and 6-methoxy-3-methyl-1,2,4-benzenetriol all act on C1q, C2, C3, C5 And C9 components.