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目的观察75例膀胱癌组织中bc1-2基因产物和突变型P53蛋白表达。方法采用免疫组化SP法。结果bc1-2和P53蛋白表达阳性率分别为40%和44%,bc1-2和P53阳性率与肿瘤侵袭性和淋巴结及远处转移有密切的关系(P<0.05),但与组织学分级无明显关系(P>0.05).结果bc1-2表达与P53在膀胱癌发生中可能起协同作用。结论bc1-2可作为评估肿瘤恶性程度、侵袭性和转移的重要参考指标之一。
Objective To observe the expression of bc1-2 gene and mutant P53 protein in 75 cases of bladder cancer. Methods Immunohistochemical SP method. Results The positive rates of bcl-2 and P53 were 40% and 44%, respectively. The positive rates of bcl-2 and P53 were closely related to tumor invasion and lymph node metastasis (P <0.05), but not to histological grade (P> 0.05) .Conclusion The expression of bcl-2 and P53 may play a synergistic role in the development of bladder cancer. Conclusion bc1-2 can be used as one of the important reference indexes to evaluate the malignant degree, invasiveness and metastasis of tumors.