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目的：探讨一氧化氮在肝硬化时的水平及作用。方法：采用银柱还原法测定35例肝硬化及20例正常对照者血浆一氧化氮代谢产物NO2－／NO3－，并同时测血清白蛋白及B超测门静脉宽度。结果：肝硬化患者血浆NO2－／NO3-水平较对照组显著增高（P＜0．05），与血清白蛋白水平呈显著负相关（P＜0．01），与门静脉宽度呈显著正相关（P＜0．01），且血中NO2-／NO3-水平随肝功能Child－pugh分级增加而升高。结论：一氧化氮在肝硬化高动力循环中起重要作用，并对肝脏的蛋白合成功能有一定影响。
Objective: To investigate the level and effect of nitric oxide in cirrhosis. Methods: Plasma nitric oxide metabolites NO2- / NO3- were measured in 35 cases of cirrhosis and 20 normal controls by silver column reduction method. Serum albumin and B-scan portal vein width were measured at the same time. Results: The level of NO2- / NO3- in plasma of cirrhotic patients was significantly higher than that of the control group (P <0.05), but negatively correlated with serum albumin level (P <0.01), and positively correlated with the width of the portal vein P <0.01), and NO2- / NO3- levels in blood increased with the increase of Child-pugh liver function. CONCLUSION: Nitric oxide plays an important role in the hyperdynamic circulation of cirrhosis and has certain effects on the protein synthesis of liver.