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目的评价四川省5.12地震灾区甲肝疫苗(HepA疫苗)群体性接种的效果。方法采用随机抽样的方法,检测四川省5个开展了灾后甲肝疫苗(HepA疫苗)群体性接种的灾区县和5个对照县1～12岁健康儿童的甲肝(HAV)IgG抗体,并比较灾区县和对照县在接种前后甲肝报告发病水平。结果灾区县1～12岁健康儿童血清HAV-IgG抗体阳性率为72.40%,对照县为39.87%(两者差异有统计学意义);灾区县在开展灾区HepA疫苗群体性接种前的3年平均发病率高于对照县,在开展接种后的2年平均发病率低于对照县,差异均有统计学意义。结论四川省5.12地震灾区HepA疫苗群体性接种产生了良好的免疫效果,有效的控制了地震后灾区甲肝的发病水平。
Objective To evaluate the effect of hepatitis B vaccine (HepA vaccine) inoculation in Sichuan Province 5.12 earthquake-hit areas. Methods A total of 5 hepatitis A (HAV) IgG antibodies were detected in 5 disaster-hit counties and 5 control counties in Sichuan Province who were immunized with HepA vaccine (HepA vaccine) And control county before and after inoculation hepatitis A report the incidence. Results The positive rate of serum HAV-IgG antibody in healthy children aged 1-12 years was 72.40% in the counties and 39.87% in the control counties (the difference was statistically significant); the average of 3 years before the HepA vaccine was vaccinated The incidence rate was higher than that of the control county. The average incidence of 2 years after inoculation was lower than that of the control county, the differences were statistically significant. Conclusion HepA vaccine inoculation in Sichuan Province 5.12 earthquake-stricken area has produced a good immune effect and effectively controlled the incidence of hepatitis A in post-quake-hit areas.