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20世纪80年代起,淋巴细胞主动免疫诱导母体妊娠期免疫耐受研究的开展,随之而来的原因不明性反复自然流产(unexplained recurrent spontaneous abortion,URSA)患者成功妊娠,无疑为URSA的治疗带来了福音。这个治疗在很长一段时间内也一直是存在争议的话题。随着近年来生殖医学的迅速发展,由免疫因素造成的不孕成为妇产科领域研究的热点。淋巴细胞主动免疫随之拓展到胚胎反复植入失败(recurrent implantation failure,RIF)和不孕症的治疗当中。
Since the 1980s, the active immunization of lymphocytes has led to the development of studies on immune tolerance in maternal pregnancy, followed by the successful pregnancy with unexplained recurrent spontaneous abortion (URSA), which is undoubtedly the treatment of URSA The gospel came. This treatment has also been a controversial topic for a long time. With the rapid development of reproductive medicine in recent years, infertility caused by immune factors has become a hot spot in the field of obstetrics and gynecology. Active immunization of lymphocytes then extends to the treatment of recurrent implantation failure (RIF) and infertility.