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目的探讨氟康唑口服治疗复发性念珠菌阴道炎的有效性和安全性。方法回顾性分析杭州市计生指导站2000年1月-2013年12月收治跟踪的160例复发性念珠菌性阴道炎患者的临床资料。其中对照组80例患者采用洁尔阴和达克宁栓剂治疗,观察组80例患者另加氟康唑口服辅助治疗,比较两组患者的治疗2周后的临床疗效及1年内复发情况。结果治疗结束后,观察组患者的总有效率为97.50%,明显高于对照组患者80.00%,组间差异有统计学意义(χ2=12.27,P<0.05),且治疗后观察组患者的白带增多、粘膜充血、疼痛等症状的例数以及1年内复发率均明显低于对照组患者,组间差异均有统计学意义(P<0.05)。结论氟康唑口服辅助治疗复发性念珠菌阴道炎具有显著的疗效,可明显改善患者的临床症状,有利于患者病情改善,降低复发率,提高了患者的生活质量,安全有效,值得临床推广和应用。
Objective To investigate the efficacy and safety of fluconazole in the treatment of recurrent Candida vaginitis. Methods The clinical data of 160 patients with recurrent candidal vaginitis who were treated in Hangzhou Family Planning Station from January 2000 to December 2013 were retrospectively analyzed. Eighty patients in the control group were treated with Jieer Yin and MDK, and 80 patients in the observation group received oral adjunctive therapy with fluconazole. The clinical efficacy and relapse within one year after the two-week treatment were compared. Results After the treatment, the total effective rate of the observation group was 97.50%, which was significantly higher than that of the control group (80.00%). There was a significant difference between the two groups (χ2 = 12.27, P <0.05) The number of cases with mucosal hyperemia and pain, as well as the recurrence rate in one year, were significantly lower than those in the control group. The differences among the groups were statistically significant (P <0.05). Conclusions Fluconazole oral adjuvant treatment of recurrent Candida vaginitis has a significant effect, can significantly improve the patient’s clinical symptoms, is conducive to the patient’s condition, reduce the recurrence rate, improve the quality of life of patients, safe and effective, worthy of clinical promotion and application.