论文部分内容阅读
目的:研究磁性纳米药物在动物体内的分布情况并考察其抑瘤效果。方法:尾静脉给予小鼠紫杉醇磁性纳米脂质体和紫杉醇脂质体,在磁性组体外施加0.5T的磁场,测定不同时间这2种药物在不同器官中的药物浓度;建立裸鼠肺癌模型,通过重量的变化比较几种药物的抑瘤效果。结果:紫杉醇磁性纳米脂质体组,在动物的肺部体外施加磁场,肺部位的药物浓度明显高于其它部位,且在给药后很快达到稳态浓度,而其它器官的药物浓度逐渐达到稳态浓度;紫杉醇脂质体组,给药后肺部位逐渐上升到稳态浓度。给予紫杉醇磁性纳米脂质体并施加磁场组的肿瘤抑制率为27.53%,显著高于紫杉醇脂质体组。结论:磁性靶向给药是一种有效的给药方式,可以将药物大量地聚集到靶部位,降低药物在正常器官的分布。
Objective: To study the distribution of magnetic nanomedicines in animals and investigate its antitumor effect. METHODS: Paclitaxel-loaded nanoliposomes and paclitaxel liposomes were administered to the tail vein of mice. The magnetic field was applied with a 0.5T magnetic field. The drug concentrations of these two drugs in different organs were measured at different times. A lung cancer model was established in nude mice. The antitumor effect of several drugs was compared by changes in weight. RESULTS: In the paclitaxel magnetic nanoliposome group, the magnetic field was applied to the outside of the animal’s lungs. The concentration of the drug in the lung site was significantly higher than that in other sites, and the steady state concentration was reached quickly after administration. The concentration of drugs in other organs gradually increased. The steady-state concentration was reached; in the paclitaxel liposome group, the lung site gradually rose to a steady state concentration after administration. The tumor inhibition rate of the group administered with paclitaxel magnetic nanoliposomes and applying a magnetic field was 27.53%, which was significantly higher than that of the paclitaxel liposome group. Conclusion: Magnetic targeted drug delivery is an effective method of administration. It can concentrate large amounts of drug on target sites and reduce the distribution of drugs in normal organs.