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Objective:To examine the the therapeutic mechhanism of Yuxingeng liquid(愈心梗液,YXGL)On early ventricular remodeling in Wistar rats with acute myocardial infarction(AMI).Methods:Measur-ing the cardiac index(CI),left ventricular weight(LVW)and cardiac myocyte dimension and observingthe concentration of endothelin(ET)and angiotensin Ⅱ(AngⅡ)in the plasma and myocardium.AMImodels were established by ligature of left anterior descending coronary artery and the rats with AMI wererandomly divided into 6 groups:the model group,sham-operation group,captopril group,high dosageYXGL group,middle dosage YXGL group and low dosage YXGL group.From the next day after model-ing,the rats had been given YXGL through the gastric tube,which lasted for 4 weeks.And then,CI,LVW and concentration of ET and AngⅡ in the plasma and myocardium were tested.Results:Comparingwith model control group,high dosage YXGL,middle dosage YXGL andcaptopril can all significantly re-duce CI,LVW,cardiac cell dimension and content of ET and Ang
Objective: To examine the therapeutic mechhanism of Yuxingeng liquid (On XXGL) On early ventricular remodeling in Wistar rats with acute myocardial infarction (AMI). Methods: Measur-ing the cardiac index (CI), left ventricular weight ( LVW) and cardiac myocyte dimension and observing the concentration of endothelin (ET) and angiotensin II (Ang II) in the plasma and myocardium. AMI models were established by ligature of left anterior descending coronary artery and the rats with AMI were randomly divided into 6 groups: the model group, sham-operation group, captopril group, high dosageYXGL group, middle dosage YXGL group and low dosage YXGL group. From the next day after model-ing, the rats had been given YXGL through the gastric tube, which lasted for 4 weeks. And then, CI, LVW and concentration of ET and AngII in the plasma and myocardium were tested. Results: Comparing with model control group, high dosage YXGL, middle dosage YXGL and captopril can all significantly re-duce CI, LVW, cardiac cell dimension and content of ET and Ang