正常组织的生长、重塑、再生以及某些组织的异常增殖均离不开充足的血液供应.而充足的血液供应又有赖于足够数量的血管形成,所以血管形成与细胞的发育、繁殖、分化、迁移、成活有密切关系。早在1971年,Folkman就提出实体性肿瘤的生长与转移需要新生血管的支持,它在肿瘤细胞的新陈代谢 Normal tissue growth, remodeling, regeneration and abnormal proliferation of certain tissues are inseparable from adequate blood supply and adequate blood supply in turn depends on a sufficient number of blood vessels, so the formation of blood vessels and cell development, reproduction, differentiation , Migration, survival is closely related. As early as 1971, Folkman proposed that the growth and metastasis of solid tumors require the support of neovascularization in the metabolism of tumor cells