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作者采用反映运动功能的定量临床参数比较了帕金森病患者对阿朴吗啡(AMP)和左旋多巴(LD)运动反应的幅度和类型。本组包括:帕金森病14例,男7女7例,平均年龄57.1岁,病程12.2年,用LD/脱羧酶抑制剂平均治疗9.8(2.7～17)年,帕金森残疾中～重度,运动功能症状性波动12例,其中重度9例。平均“关”期Hoehn和Yahr分级3.3。实验前晚停用所有抗帕金森治疗后于清晨进行,头天口服LD250mg/卡比多巴25mg,次日皮下注射AMP,平均2mg(1～4mg),注射前2小时口服哌双咪酮(domperidon)20mg,用药期间空腹,每隔5～15分观察运动功能,直至运动反应
The authors compared the magnitude and type of Parkinson’s disease response to apomorphine (AMP) and levodopa (LD) motility using quantitative clinical parameters that reflect motor function. This group includes: Parkinson’s disease in 14 cases, 7 males and 7 females, mean age 57.1 years, duration of 12.2 years, with LD / decarboxylase inhibitor average treatment of 9.8 (2.7 to 17 years), Parkinson disabled ~ severe, exercise Symptoms of functional fluctuations in 12 cases, of which 9 cases of severe. Average “off” period Hoehn and Yahr grading 3.3. Parkinson’s disease was stopped in the early morning of the experiment, and LD250mg / carbidopa 25mg the first day and AMP subcutaneously 2mg (1-4mg) on the next day. Domperidon ) 20mg, fasting during the medication, every 5 to 15 minutes observed motor function, until the motor response