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用抗Ｐ５３的单克隆抗体对３５例膀胱移行上皮细胞癌组织进行免疫组化研究。结果３５例癌组织中Ｐ５３阳性核染者１７例，占４８．５７％；Ｐ５３阳性细胞的分布方式有均衡分布、不均衡分布及散在分布三种，与病理分期的关系为：均衡分布：ＰＴ１２例，ＰＴ２７例，ＰＴ３１例；不均衡分布：ＰＴ１１例，ＰＴ２２例；散在分布：ＰＴ２３例，ＰＴ３４例。认为Ｐ５３阳性细胞的分布方式对肿瘤的生物学行为和预后的判定有特殊意义。
35 cases of bladder transitional cell carcinoma were immunohistochemically studied with anti-P53 monoclonal antibody. Results Among the 35 cases of P53 positive nuclear infection, 17 cases were found, accounting for 48.57%. There were three types of distribution of P53 positive cells: unbalanced distribution and scattered distribution. The distribution of P53 positive cells was: Balanced distribution: PT12 Cases, PT27 cases, PT31 cases; uneven distribution: PT11 cases, PT22 cases; scattered distribution: PT23 cases, PT34 cases. That the distribution of P53 positive cells on the biological behavior of the tumor and the prognosis of a special significance.