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目的分析探讨促血管生成素-1(Ang-1)与反复自然流产(RSA)的临床相关性。方法反复自然流产患者51例为观察组,并收集同期健康人工流产患者39例为对照组,检测收集的两组患者绒毛膜组织上的Ang-1的蛋白表达水平,并对两组患者的检测结果进行比较分析。结果两组患者经过检测后发现,自然流产组患者绒毛膜组织上的Ang-1的表达阳性率92.16%明显高于人工流产组患者的Ang-1的表达阳性率66.67%,差异有统计学意义(P<0.05)。结论 Ang-1的蛋白高度表达与反复自然流产有相关性,可能是RSA的病因之一。
Objective To investigate the clinical relevance of angiopoietin-1 (Ang-1) and recurrent spontaneous abortion (RSA). Methods Fifty-one patients with recurrent spontaneous abortion were randomly divided into observation group and 39 healthy abortion patients in the same period as control group. The expression of Ang-1 protein in chorionic tissue of the two groups was detected, and the detection of two groups The results of comparative analysis. Results After two groups of patients were tested, the positive rate of Ang-1 expression on chorionic tissue in patients with spontaneous abortion was 92.16%, which was significantly higher than that in induced abortion group (66.67%), the difference was statistically significant (P <0.05). Conclusion The high expression of Ang-1 protein is associated with recurrent spontaneous abortion and may be one of the causes of RSA.