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目的:通过进行Meta分析评价植物雌激素(PE)治疗围绝经期综合征(MPS)的效果。方法:通过检索万方、Pub Med数据库中关于PE的对照文章,用Meta分析方法对数据进行处理,评估其加权均数差、比值比、95%可信区间,比较有效例数,kupermen评分等。结果:本研究共纳入了6篇文献中的616例MPS的患者。结果显示PE对比激素替代疗法(HRT)的有效例数,差异具有统计学意义[OR=0.46,95%CI(0.26,0.82),P=0.005],更低的kuppermen评分对比,差异具有统计学意义[WND=–0.87,95%CI(–1.47,–0.26)P=0.008];但是雌二醇,促卵泡生成素,孕酮组间比较,差异无统计学意义(P>0.05)。结论:在治疗MPS时,PE可以提高治疗的有效率、降低患者的主观症状。但目前尚无足够证据证明PE可以调节内分泌。
OBJECTIVE: To evaluate the efficacy of phytoestrogen (PE) in the treatment of menopausal syndrome (MPS) by performing meta-analysis. Methods: By searching the articles about PE in PubMed database, the data were processed by Meta analysis to evaluate the weighted mean difference, odds ratio, 95% confidence interval, the number of effective cases, kupermen score and so on . Results: A total of 616 MPS patients from 6 articles were included in this study. The results showed that the effective number of PE contrast hormone replacement therapy (HRT), the difference was statistically significant [OR = 0.46,95% CI (0.26,0.82), P = 0.005], lower kuppermen score comparison, the difference was statistically significant Significance [WND = -0.87, 95% CI (-1.47, -0.26) P = 0.008]; but estradiol, follicle stimulating hormone, progesterone were no significant difference between groups (P> 0.05). Conclusion: When treating MPS, PE can improve the efficiency of treatment and reduce the subjective symptoms of patients. However, there is not enough evidence to prove that PE can regulate endocrine.