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作者对近亲繁殖的C-57黑色小鼠长期(13周)给予D-半乳糖胺(GalN)及其佐剂,建立了慢性活动性肝炎的动物模型。众所周知,GalN可引起肝内代谢和蛋白合成紊乱。长期反复注射GalN可以产生肝坏死。同时使用佐剂则是为了影响宿主的免疫反应。本试验中应用的佐剂有Freund完全佐剂(FCA)和Freund不完全佐
The author inbred C-57 black mice long-term (13 weeks) given D-galactosamine (GalN) and its adjuvant, the establishment of an animal model of chronic active hepatitis. As we all know, GalN can cause liver metabolism and protein synthesis disorders. Long-term repeated injection of GalN can produce liver necrosis. Adjuvants are used simultaneously to affect the host’s immune response. The adjuvants used in this trial were Freund’s complete adjuvant (FCA) and Freund’s incomplete adjuvant