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目的通过对各型肝病患者血清肝纤维化四项和r-谷氨酰基转移酶(GGT)和凝血酶原时间(PT)的检测与分析,判断各型肝病患者纤维化指标。方法对住院95例各型肝病患者进行肝纤维化四项即透明质酸(HA)、Ⅲ型前胶原肽(PⅢNP)、Ⅳ型胶原(ⅣC)、层黏连蛋白(LN)及GGT和PT检测。结果中重度慢性肝病患者肝纤维四项升高明显,与对照组比较差异有统计学意义(P<0.01);急性肝炎PT和GGT指数无明显的改变;慢性轻度肝炎时,肝纤维四项及PT和GGT均轻度升高。中重度慢性肝炎患者中,肝纤维四项有较高的灵敏度,HA的灵敏度较高,为肝纤维化最敏感的诊断指标。结论通过肝纤维化四项及血清GGT和PT的联合检测,结果可作为判断慢性肝病患者肝纤维化的常规指标,为临床药物抗肝病纤维化治疗提供依据。
Objective To detect and analyze the serum levels of hepatic fibrosis and r-glutamyltransferase (GGT) and prothrombin time (PT) in patients with various liver diseases to determine the indexes of fibrosis in patients with various liver diseases. Methods Ninety-five patients with liver disease were enrolled in the study. Four items of hepatic fibrosis such as HA, PⅢNP, ⅣC, LN, GGT and PT Detection. Results There was significant increase in four items of liver fibrosis in patients with moderate-severe chronic liver disease (P <0.01), no significant changes in PT and GGT index in acute hepatitis, And PT and GGT were mildly elevated. In patients with moderate to severe chronic hepatitis, liver fibrosis has four high sensitivity, high sensitivity of HA, liver fibrosis is the most sensitive diagnostic indicators. Conclusion The results of four combined tests of serum GGT and PT in liver fibrosis can be used as a routine index for judging hepatic fibrosis in patients with chronic liver disease and provide a basis for the clinical treatment of fibrosis with liver fibrosis.