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目的:随访口服三苯氧胺的乳腺癌患者,观察在随访期内发生的子宫内膜病理改变类型。方法:80例乳腺癌患者口服三苯氧胺20mg/日,每隔6个月作双合诊检查及子宫内膜活体组织检查。结果:可评价患者共67例,共行200次子宫内膜活检,60例仍为正常子宫内膜表现,TAM应用中位持续时间30个月。2例绝经前患者子宫内膜活检表现为单纯性增生过长,1例绝经后患者表现为萎缩性子宫内膜与复合性增生过长并存,1例绝经后患者切除子宫,术后内膜病理表现为增生性息肉、单纯性囊性增生。7例患者发生子宫内膜息肉。结论:长期口服三苯氧胺在绝经前后患者中均能发生子宫内膜单纯性增生过长、复合性增生过长及息肉改变,未见有癌的发生。
OBJECTIVE: To follow up the oral tamoxifen in patients with breast cancer and observe the type of endometrial pathological changes during the follow-up period. Methods: 80 cases of breast cancer patients oral administration of tamoxifen 20mg / day, every 6 months for double check examination and endometrial biopsy. Results: A total of 67 evaluable patients had a total of 200 endometrial biopsies, and 60 were still normal endometrium. The median duration of TAM was 30 months. Two cases of premenopausal women with endometrial biopsy showed simple hyperplasia, a case of postmenopausal patients showed atrophic endometrial and multiple hyperplasia coexist, one case of postmenopausal patients with uterine resection, postoperative endometrial pathology The performance of hyperplastic polyps, simple cystic hyperplasia. Seven patients developed endometrial polyps. Conclusion: Long-term oral administration of tamoxifen in patients with premenopausal women can occur in simple hyperplasia of endometrial hyperplasia, complex hyperplasia and polyps change, no cancer.