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目的:探讨抗柯萨奇病毒B病毒性心肌炎胶囊(K-CoxB-JN)对于阿霉素(ADM)诱导小鼠心肌损伤模型的保护作用。方法:将小鼠随机分为5组,正常对照组、模型组、K-CoxB-JN低剂量组、K-CoxB-JN中剂量组、K-CoxB-JN高剂量组,观察K-CoxB-JN对心肌组织病理、小鼠心脾指数、小鼠血清血清肌酸激酶(CK)、乳酸脱氢酶(LDH)、心肌肌钙蛋白I(cTn)I的影响。结果:K-CoxB-JN低、中、高剂量组炎性和坏死病理改变明显轻于模型组;K-CoxB-JN中、高剂量组的心脏指数与模型组比较,差异均有非常显著性意义(P<0.01),K-CoxB-JN中剂量组的小鼠脾脏指数与模型组比较,差异有显著性意义(P<0.05);K-CoxB-JN低、中、高剂量组CK和cTnI的值均降低,与模型组比较,差异均有非常显著性意义(P<0.01),K-CoxB-JN中剂量组LDH的值降低,与模型组比较,差异有显著性意义(P<0.05)。结论:K-CoxB-JN对心肌损伤小鼠血清CK、LDH、cTnI有抑制作用,K-CoxB-JN对心肌具有保护作用。
Objective: To investigate the protective effect of K-CoxB-JN against adriamycin-induced myocardial injury in mice. Methods: The mice were randomly divided into 5 groups: normal control group, model group, K-CoxB-JN low dose group, K-CoxB-JN middle dose group and K-CoxB-JN high dose group. JN on myocardial histopathology, heart and spleen index in mice, serum creatine kinase (CK), lactate dehydrogenase (LDH) and cardiac troponin I (cTn) I in mice. Results: K-CoxB-JN low, medium and high dose groups of inflammatory and necrotic pathological changes were significantly lighter than the model group; K-CoxB-JN medium and high dose group of cardiac index compared with the model group, the difference was significant (P <0.01). Compared with model group, the spleen index of K-CoxB-JN medium dose group had significant difference (P <0.05) (P <0.01). The LDH value of K-CoxB-JN middle dose group was lower than that of model group (P <0.01), and the difference was significant (P < 0.05). Conclusion: K-CoxB-JN can inhibit the serum CK, LDH and cTnI in mice with myocardial injury, and K-CoxB-JN has a protective effect on myocardium.