可待因单独用药或与朴热息痛、阿斯匹林等合并用药治疗疼痛已经多年,但在人体中的药代动力学研究较少。而在肾衰病人中的药代动力学和药效动力学研究更少。本文报告了正常人和长期血液透析状态下的肾衰病人口服和静注单剂量可待因后,原药与三种主要代谢产物的药代动力学和药效动力学。 Codeine alone or in combination with Parketracil, aspirin and other pain medication for many years, but less in the human body pharmacokinetic studies. In the renal failure patients pharmacokinetics and pharmacodynamics less. This article reports the pharmacokinetics and pharmacodynamics of the primary drug and the three major metabolites after oral and intravenous single-dose codeine administration in normal and long-term hemodialysis patients with renal failure.