作者报告1974～1986年质子放疗的68例颅底脊索瘤和低恶性软骨肉瘤。经CT与MRI均明确肿瘤位于斜坡,扩展范围包括蝶窦、鼻咽部、岩骨、鞍旁与上颈椎。均作过活检或次全切,其中6例作了第2次手术,均有残存,无远处转移。术后(4例亦作了术前)用160MeV质子线,它的生物效应较~(60)钴大10%,用CGE表示(与~(60)钴Gy同等单位):质子Gy剂量乘以1.1。用多维治疗计划系统,靶区与邻近正常结构均明确显示,每周5天(质子4 The authors report 68 cases of skull base chordoma and low-grade chondrosarcoma treated with proton-radiotherapy from 1974 to 1986. By CT and MRI are clearly located in the slope of the tumor, the scope of expansion, including sphenoid sinus, nasopharynx, petrous bone, parasellar and upper cervical spine. All had biopsy or subtotal resection, of which 6 cases made the second surgery, all survived without distant metastasis. The biological effect of 160 MeV protons after surgery (4 patients were also preoperatively) was 10% greater than ~ (60) cobalt and was expressed as CGE (equivalent to ~ (60) cobalt Gy) by multiplying the proton Gy dose by 1.1. With a multidimensional treatment planning system, the target area and adjacent normal structures are clearly shown, 5 days a week (Proton 4