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因硒、维生素A和E对发生癌的效应证据不足且有争论。作者在芬兰东部作了前瞻性研究:分析了诊断癌前的血清硒,维生素A和E的单独和连合浓度,与以后因癌而死亡的危险关系。调查包括1977年芬兰东部二个省中年龄30～64岁人群随机抽样6.7%,这个人群摄食异常高的饱和脂肪和胆固醇。共检查12,155人,在4年随访中56名受检者死于癌。每一病例有一对照受检查,根据相同性别、年龄、每天吸烟情况(吸烟或不吸烟,以及吸烟数)与这些病例配对比较,共分析51病例和51名相互配对的对照者。
There is insufficient and controversial evidence that the effects of selenium, vitamins A and E on cancer occur. In a prospective study in eastern Finland, the authors analyzed individual and combined concentrations of serum pre-cancerous selenium, vitamins A and E, and the risk of death from cancer later on. The survey included a random sample of 6.7% of the population aged 30-64 in two provinces of Eastern Finland in 1977, who consumed abnormally high levels of saturated fat and cholesterol. A total of 12,155 people were examined, 56 of whom died of cancer at 4 years of follow-up. In each case, a control was examined and compared to these cases based on the same sex, age, daily smoking status (smoking or not, and number of cigarettes), and 51 cases and 51 matched controls were analyzed.