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本文总结了复方甲孕环酯(首称复方孕素1号)十年来的临床研究。结果表明,于月经周期的第十天(大约排卵前3—5天)服药二片、第十六天再服一片(内含甲地孕醇-3-环戊烷丙酸酯50毫克、炔雌醚0.25毫克),经试用1213例、共9651月经周期,妇女年避孕有效率达99.1%。对830例服药者的副反应调查中,173例(占20.8%)有不同程度的副反应,一般持续一天.绝大多数人的经期、经量正常。药物安全性随访观察,未见不良反应。停药后观察的七例,均能生育。临床使用中存在的主要问题是部分妇女的月经周期缩短,其中以年轻的妇女发生率较高.
This article summarizes the clinical research of compound mepirtone (the first compound progestogen No.1) for ten years. The results showed that on the tenth day of the menstrual cycle (about 3-5 days before ovulation), two tablets were taken on the sixteenth day (50 mg of megestrol-3-cyclopentane propionate, Estrogen 0.25 mg), the trial of 1213 cases, a total of 9651 menstrual cycle, women’s annual contraception, the effective rate of 99.1%. Of the 830 respondents with side effects survey, 173 patients (20.8%) had different degrees of side effects, usually lasts for one day, while most people have normal menstruation and normal menstruation. Drug safety follow-up observation, no adverse reactions. Observed after stopping the seven cases, can have children. The main problem in clinical use is the shortening of the menstrual cycle in some women, with a higher incidence of young women.