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胰岛素抵抗是非酒精性脂肪性肝炎(NASH)发病机制的关键因素。细胞因子脂联素(adiponectin) 具有增加胰岛素敏感性、抗炎症和抗动脉粥样硬化的作用。而脂联素受体(AdipoR)在adiponectin激活AMPK、增加PPARα配体活性、增加葡萄糖摄取和脂肪酸氧化时发挥介导作用。因此,对adiponectin及AdipoR的进一步研究有助于对NASH的机制和治疗有更好的认识。
Insulin resistance is a key factor in the pathogenesis of non-alcoholic steatohepatitis (NASH). The cytokine adiponectin has an effect of increasing insulin sensitivity, anti-inflammation and anti-atherosclerosis. AdipoR (adiponectin) activates AMPK, which increases the activity of PPARα ligand and increases the glucose uptake and fatty acid oxidation. Therefore, further study of adiponectin and AdipoR will help to better understand the mechanism and treatment of NASH.