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女性患者在肝移植或肝细胞肿瘤切除术后较男性患者有更好的生存率。雌激素可通过非基因和(或)基因反应增加内皮细胞一氧化氮合酶(eNOS),催化一氧化氮(NO)产生,而NO在限制全肝缺血再灌注损伤中起着重要作用,本实验观察NO在雌性大鼠肝缺血再灌注中的保护机制。
Female patients have a better survival rate than male patients after liver transplantation or hepatocellular tumor resection. Estrogen can increase endothelial nitric oxide synthase (eNOS) and catalyze the production of nitric oxide (NO) through non-gene and / or gene reaction, while NO plays an important role in limiting total hepatic ischemia-reperfusion injury. This experiment observed NO in rat liver ischemia-reperfusion protective mechanism.