【摘 要】
：
INTRODUCTIONrnPrimary bone cancer is relatively rare, but bone is a frequent site of cancer metastases.1–2 Estrogen receptor (ER)-positive cancers preferentially metastasize to bone,3 but bone is also a common site of metastasis of ER-negative breast canc
【机 构】
：
Department of Biomedical Engineering,Indiana University Purdue University Indianapolis,Indianapolis,
论文部分内容阅读
INTRODUCTIONrnPrimary bone cancer is relatively rare, but bone is a frequent site of cancer metastases.1–2 Estrogen receptor (ER)-positive cancers preferentially metastasize to bone,3 but bone is also a common site of metastasis of ER-negative breast cancers, including triple-negative breast cancer.4 Many potential reasons for the high rate of bone metastasis, including chemotaxis mediated by cytokines, chemokines, and TGFβ-rich calcified matrix as a metastatic environment, have been considered.5 However, the role of osteocytes, which are the most abundant type of bone cells, in this process remains poorly understood.6 Focusing on the role of Wnt signaling, which is required for load-driven bone home-ostasis, we evaluated the interactions of tumor cells with mechanosensitive osteocytes.
其他文献
高血压伴短指(趾)畸形综合征(hypertension and brachydactyly syndrome,HTNB,在线人类孟德尔遗传数据库编号OMIM#112410)是一种常染色体显性遗传性高血压伴E型短指(趾),属于单基因遗传性高血压之一,于1973年由Bilginturan等首先在1个土耳其家族中发现,故又称Bilginturan综合征,其致病基因为磷酸二酯酶3A (phosphodiesterase 3A,PDE3A)基因[1-2].HTNB在临床上表现为年龄依赖性高血压,如不治疗,通常在50
[目的]探讨健胃愈脑汤联合多奈哌齐对轻中度阿尔茨海默病(AD)气血亏虚证患者智力状态、精神行为及海马波谱的影响.[方法]选取89例轻中度AD气血亏虚证患者,根据治疗方案的不同进行分组,对照组44例予多奈哌齐片口服,观察组45例在对照组用药基础上加用健胃愈脑汤(陈皮15 g,当归15 g,白术15 g,茯神10 g,天麻10 g,红景天10 g,党参6 g,甘草6g)口服治疗,两组均连续治疗120 d,观察两组临床疗效、智力状态、精神行为及海马波谱表现.[结果]干预后,观察组患者简易智力状态检查(MMSE)
INTRODUCTIONrnThe musculoskeletal system (MSK), including bone, cartilaginous tissues, skeletal muscle, tendon, ligament, intervertebral disc, and others, is the structural framework for the body and enables movement. Bones are held in position by ligamen
[目的]观察头针联合肌电生物反馈疗法治疗脑卒中后抑郁症患者的疗效.[方法]将60例脑卒中后抑郁症患者随机分为2组,各30例,对照组予常规抗抑郁药物治疗,治疗组在对照组基础上运用头针联合肌电生物反馈疗法,每天1次,每次30 min,4周为1个疗程,2个疗程后观察结果.治疗前后采用24项汉密尔顿抑郁量表(HAMD-24)、Barthel指数评定量表(BI)、简易精神状态检查(MMSE)进行评估.[结果]对照组总有效率为73.33％,治疗组为93.33％,两组比较有显著性差异(P＜0.05).治疗前后比较,两组
INTRODUCTIONrnMechanotransduction is a fundamental ability that allows living organisms to receive and respond to physical signals from the internal and external environment and has been found and characterized in all five kingdoms of life. For bacteria o
INTRODUCTIONrnTissue engineering aims to study and develop new methods for the replacement of damaged or diseased tissue. The fundamental idea is to use the appropriate type of cells, seed them on suitable support materials, induce controlled cell differe
[目的]观察消脂化浊健脾法治疗非酒精性脂肪性肝病(NAFLD)痰瘀互结证的效果及其对胰岛素抵抗水平、影像学参数及肠道菌群失调状态的影响.[方法]将109例NAFLD患者按随机数字表法分为两组,对照组54例给予多烯磷脂酰胆碱胶囊口服,每次456 mg,每日3次.观察组55例在对照组治疗的基础上加用消脂化浊健脾法(药物组成:白术、白芍、泽泻各15 g,茵陈20 g,茯苓20 g,延胡索、地龙、桃仁、丹参各10 g,香附、茜草各5 g)治疗,两组疗程均为3个月.[结果]观察组总有效率为90.91％,对照组总有效
目的:观察当归通痹汤联合复方倍他米松治疗膝关节骨性关节炎(KOA)的临床疗效.方法:选取2018年9月至2020年8月收治的134例膝关节骨性关节炎患者,随机分为观察组和对照组,对照组予关节腔注射复方倍他米松治疗,观察组在对照组基础上联合当归通痹汤治疗,观察两组治疗前后Lysholm膝关节评分(LKS)、西安大略和麦克马斯特大学骨关节炎指数(WOMAC)、日常生活活动能力(ADL)评分及炎性因子水平的改善情况,比较临床疗效.结果:治疗前两组LKS、WOMAC、ADL评分无显著性差异(P＞0.05),治疗后
目的:探讨防治新型冠状病毒肺炎的中药组方配伍规律,为中医药治疗新型冠状病毒肺炎提供依据,促进中药抗疫应用及开发.方法:收集现代期刊文献(2019-2020年)所记载的防治新型冠状病毒肺炎的方剂,筛选出121首治疗新型冠状病毒肺炎的方剂,参照《中药学》《中华人民共和国药典》对药名进行规范,提取相关信息,将数据进行标准化整理后录入中医传承辅助软件(V2.5),运用频次统计、关联规则分析、熵聚类分析研究防治新型冠状病毒肺炎方剂的配伍规律.结果:在121首方剂中,共涉及232味中药,除了甘草作为使药在方剂中得到广
[目的]观察化疗结合蒙药治疗晚期肺癌的疗效.[方法]将符合纳入标准的晚期肺癌患者60例随机分为对照组和治疗组,每组30例.对照组予常规化疗,治疗组予常规化疗结合口服桑塔勒-25味等蒙药治疗.两组均以21 d为1个化疗周期,2个周期后统计近期临床疗效、生存时间及生活质量情况.[结果]治疗组总有效率与疾病控制率分别为66,67％、83.33％,高于对照组的46.67％、60.00％,其中疾病控制率差异具有统计学意义(P＜0.05).治疗组3个月时生存率与对照组无显著差异(P＞0.05),6个月、1年及2年生存