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目的 研究人肝胆管癌组织中Ki - 6 7抗原和TGFβ1的表达及意义。 方法 应用免疫组化S -P法对 57例人肝胆管癌组织石蜡切片行Ki6 7抗原和TGFβ1染色分析。 结果 1.肝胆管癌Ki6 7指数 (35 9± 2 0 0 )显著高于肝胆管结石症和正常肝内胆管 (P <0 0 0 1) ,并随癌分化程度的降低而增高 (P <0 0 0 1) ;淋巴结转移组Ki6 7指数高于无淋巴结转移组 (P <0 0 1)。 2 .癌组织中TGFβ1表达与淋巴结转移呈正相关 (P <0 0 1)。 3.TGFβ1表达与Ki6 7抗原呈正相关 ,(P <0 0 1)。结论 Ki6 7抗原可应用临床判断肿瘤转移危险性和估计预后。TGFβ1表达异常与肝胆管癌的发生、发展有关。
Objective To study the expression and significance of Ki-67 antigen and TGFβ1 in human hepatobiliary carcinoma. Methods Immunohistochemical S-P method was used to analyze Ki67 antigen and TGFβ1 staining in paraffin sections of 57 cases of human hepatobiliary carcinoma. Results 1. The Ki67 index (35 9±200) of hepatobiliary carcinoma was significantly higher than that of hepatolithiasis and normal intrahepatic bile duct (P < 0.01), and it increased with the decrease of the degree of differentiation (P < 0 0 0 1) ; The lymph node metastasis group Ki67 index was higher than the group without lymph node metastasis (P <0 01). 2. There was a positive correlation between TGFβ1 expression and lymph node metastasis in cancer tissues (P <0 01). 3. TGFβ1 expression was positively correlated with Ki67 antigen (P <0 01). Conclusion Ki67 antigen can be used clinically to judge the risk of tumor metastasis and to estimate the prognosis. The abnormal expression of TGFβ1 is related to the occurrence and development of hepatobiliary cancer.