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目的探讨川崎病(KD)患儿血浆中抗β2糖蛋白1(β2GP1)抗体水平及其临床意义。方法采用ELISA法检测20例KD患儿血浆中抗β2GP1抗体水平,并与正常儿童组对照。结果20例KD患儿,临床诊断时间平均9.8d,冠状动脉扩张(CAD)发生率60%(12/20),冠状动脉瘤(CAA)发生率25%(5/20)。抗β2GP1抗体阳性15例,阳性率为75%(15/20),抗β2GP1抗体水平用A492值表示为0.909±0.310,正常对照组A492值为0.351±0.154,两者比较有显著性差异(t=6.566,P﹤0.001)。12例CAD患儿A492为1.119±0.1,8例无CAD患儿A492为0.593±0.24,二者比较有显著性差异(t=2.404,P﹤0.05)。结论KD患儿血浆中存在高水平的抗β2GP1抗体,并发冠脉损伤的KD患儿抗β2GP1抗体水平明显高于未并发冠脉损伤的患儿。提示抗β2GP1抗体是KD冠状动脉损伤的一种重要危险因子。
Objective To investigate the plasma levels of anti-β2GP1 antibody in children with Kawasaki disease (KD) and its clinical significance. Methods The level of anti-β2GP1 antibody in 20 children with KD was detected by ELISA and compared with that of normal children. Results Twenty patients with KD had an average clinical diagnosis time of 9.8 days, a CAD rate of 60% (12/20), and a coronary artery aneurysm (CAA) rate of 25% (5/20). Anti-β2GP1 antibody positive in 15 cases, the positive rate was 75% (15/20), anti-β2GP1 antibody level with the A492 value was 0.909 ± 0.310, the normal control group A492 value was 0.351 ± 0.154, the two were significantly different (t = 6.566, P <0.001). The A492 of 12 children with CAD was 1.119 ± 0.1, and that of 849 children with CAD without CAD was 0.593 ± 0.24 (t = 2.404, P <0.05). Conclusions There is a high level of anti-β2GP1 antibody in the plasma of children with KD, and the level of anti-β2GP1 antibody in KD patients with coronary artery injury is significantly higher than that in children without coronary artery lesion. Tip anti-β2GP1 antibody KD coronary artery injury is an important risk factor.