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用体外培养技术观察了吡喹酮对日本血吸虫肝门型童虫活动及存活情况的影响。童虫接触较低浓度(1μg/ml以下)吡喹酮后表现为短时间兴奋,继而出现轻度挛缩,虫体活动减弱,换正常培养基后活动很快恢复并能正常存活;而接触较高浓度(1μg/ml以上)吡喹酮后,童虫立即出现强直性挛缩,活动几乎停止,短时间(6h内)换正常培养基童虫活力尚可恢复并能正常存活,延长与药物接触时间童虫活力不能恢复,继续培养时也不能存活。
The effect of praziquantel on the activity and survival of Schistosoma japonicum Schistosoma japonicum was observed in vitro. Schizophrenia showed potent short-term stimulation after exposure to praziquantel at a lower concentration (1 μg / ml or less), followed by mild contracture, which attenuated the activities of parasites and returned to normal after normal medium replacement Immediately after treatment with praziquantel at high concentration (1μg / ml), the contractile activity was almost stopped immediately after the praziquantel treatment. In a short period of time (within 6h), the activity of the normal worm was restored and survived, prolonging the contact with drug Time can not restore the energy of the squirrels, continue to cultivate can not survive.