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研究恶性阻塞性黄疸手术后早期肠内营养支持（EEN）与全肠外营养支持（TPN）对肝、肾功能的影响。方法将36例恶性阻塞性黄疸病人术后随机分为EEN组（16例）和TPN组（20例），均于术后第2d（48h内）开始进行营养支持，EEN液经空肠造口管以肠内营养输注泵滴入， TPN液经深静脉置管滴入。术前及术后第5、7d监测肝、肾功能，进行统计学分析。结果肝功能检测值EEN组恢复速度较TPN组快，其中血总胆红素（TB）和r-谷氨酰转肽酶（r-GT）于术后第7d时两组差异有统计学意义。肾功能检测值EEN组术后升高幅度较TPN组低、恢复较快，其中尿转铁蛋白（TRF）、N-2酰-β-D-氨基葡萄苷酶（NAG）、α-微球蛋白（α1-mG）于术后第7d两组差异有统计学意义。结论早期肠内营养支持在促进恶性阻塞性黄疸术后肝、肾功能恢复方面优于全肠外营养支持。“,”Objective To investigate the effect of EEN and TPN on liver and renal function in post-poerative patients with malignant obstructive jaundice. Methods 36 cases with malignant obstructive jaundice admitted beween were randomized to receive postoperative TPN(n=20)or EEN(n=16)Their liver and renal functions were measured before operation and post-poerative day 5 and 7,respectively. Results liver function in EEN group recovered more guickly than those in TPN group after operation. The levels of TB and r-GT were significantly cower on the 7 h day after operation compared to those in TPN group. Renal function in EEN group came down faster than those in TPN group. The levels of TRF. NAG and α1-mG were significantly lower on the 7h day after operation compared to those in TPN group. Conclusion EEN may present better protective to wards liver and renal function compared to TPN in the patients with malignant obstructive jaundice after operation.