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[目的]了解深圳地区反复自然流产妇女和正常妇女凝血因子XⅢ(FXⅢ)基因Val34Leu的多态性,探讨其与反复自然流产发病的关系。[方法]应用聚合酶链反应-限制性片段长度多态性分析方法(PCR-RFLP)检测57例反复自然流产妇女和153例正常妇女的FXⅢ Val34Leu基因多态性。[结果]反复自然流产组与正常对照组均不存在FXⅢ Val34Leu的突变。[结论]深圳地区正常妇女和反复自然流产妇女FXⅢ Val34Leu的突变频率很低,FXⅢ Val34Leu的突变可能不是引起反复自然流产发病的重要原因。
[Objective] To investigate the polymorphism of Val34Leu gene in patients with recurrent spontaneous abortion and normal women in Shenzhen and to explore its relationship with recurrent spontaneous abortion. [Method] The PCR-RFLP was used to detect the polymorphism of FXIII Val34Leu in 57 cases of recurrent spontaneous abortion and 153 cases of normal women. [Result] The mutation of FXIII Val34Leu did not exist in recurrent spontaneous abortion group and normal control group. [Conclusion] The mutation frequency of FXIII Val34Leu in normal women and recurrent spontaneous abortion in Shenzhen area is very low. The mutation of FXIII Val34Leu may not be the important cause of recurrent spontaneous abortion.