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[目的]了解哈尔滨市新生儿多环芳烃(PAHs)负荷水平,探索其影响因素。[方法]于2013年4—9月在哈尔滨某医院随机选择孕妇-新生儿200对,收集孕妇和新生儿的基本信息,抽取孕妇分娩时新生儿脐带血,采用气相色谱-质谱联用检测新生儿脐带血中18种多环芳烃的含量,采用Spearman秩相关分析影响新生儿PAHs水平的暴露因素。[结果]新生儿脐带血中可检出18种PAHs,其中致癌PAHs检出7种。苯并[a]蒽和检出率分别为63%和74%,其余5种致癌PAHs检出率均在80%以上,7种致癌PAHs质量浓度之和市区(中位数,13.90μg/L;P25~P75,4.87~20.12μg/L)明显高于郊区(中位数,7.01μg/L;P25~P75,2.39~14.00μg/L)(P<0.05)。Spearman秩相关分析表明,脐带血中4种非致癌性PAHs(萘、菲、蒽、荧蒽)和5种致癌性PAHs(、苯并[a]蒽、苯并[a]芘、二苯并[a,h]蒽、茚并[1,2,3-cd]芘)质量浓度的升高与孕妇居住在市区、居住地附近有主干道、孕期被动吸烟、摄入PAHs高的饮食结构有关(P<0.05)。[结论]哈尔滨市新生儿脐血中可检测出多种致癌PAHs,并且孕妇居住在市区、居住地附近有主干道、孕期被动吸烟、摄入PAHs高的饮食结构是新生儿PAHs暴露的危险因素。
[Objective] To understand the load of neonatal polycyclic aromatic hydrocarbons (PAHs) in Harbin and to explore the influencing factors. [Methods] From April to September in 2013, 200 pairs of pregnant women and newborns were randomly selected in a hospital in Harbin to collect the basic information of pregnant women and newborns. The cord blood of newborns at the time of delivery was taken out by pregnant women and detected by gas chromatography-mass spectrometry 18 cord blood polycyclic aromatic hydrocarbons content, using Spearman rank correlation analysis of newborn PAHs exposure factors. [Result] Eighteen kinds of PAHs were detected in neonatal cord blood, of which seven were carcinogenic PAHs. The detection rates of anthracene and benzo [a] anthracene were 63% and 74%, respectively. The detection rates of the other five carcinogenic PAHs were above 80%. The sum of the concentrations of seven carcinogenic PAHs in the urban area (median, 13.90μg / L; P25 ~ P75,4.87 ~ 20.12μg / L) were significantly higher than those in the suburbs (median, 7.01μg / L; P25 ~ P75,2.39-14.00μg / L) (P <0.05). Spearman rank correlation analysis showed that four noncarcinogenic PAHs (naphthalene, phenanthrene, anthracene, fluoranthene) and five oncogenic PAHs (benzo [a] anthracene, benzo [a] pyrene, [a, h] Anthracene, indeno [1,2,3-cd] pyrene) Elevated mass concentrations in pregnant women living in urban areas with main roads near their homes, passive smoking during pregnancy, and high dietary intake of PAHs Related (P <0.05). [Conclusion] A variety of carcinogenic PAHs can be detected in neonatal umbilical cord blood of Harbin, and pregnant women live in the urban area with main road near their place of residence and passive smoking during pregnancy. The dietary structure with high intake of PAHs is the risk of neonatal PAHs exposure factor.