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通过侧链悬挂固相法合成了Ｃ端二乙胺基保护及用Ｇｌｕ取代Ｔｈｒ３１的鲑降钙素类似物［Ｇｌｕ３１，Ｐｒｏ３２－Ｎ（Ｃ２Ｈ５）２］ｓＣＴ，以降低Ｃ端酰胺基的降解，增加肽的稳定性。用圆二色谱（ＣＤ）法研究了肽［Ｇｌｕ３１，Ｐｒｏ３２－Ｎ（Ｃ２Ｈ５）２］ｓＣＴ在水及三氟乙醇（ＴＦＥ）中的二级结构。它在大鼠体内的降钙活性为５２７６．９ＩＵ／ｍｇ。
C-terminal diethylamino-protected and salmon calcitonin analogues [Glu31, Pro32-N (C2H5) 2] sCT with Glu substitution of Thr31 were synthesized by side-chain suspension to reduce the degradation of the C-terminal amide group, Increase the stability of the peptide. The secondary structure of peptide [Glu31, Pro32-N (C2H5) 2] sCT in water and trifluoroethanol (TFE) was investigated by circular dichroism (CD) Its calcium-lowering activity in rats was 5276.9 IU / mg.