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维达芮丙(腺嘌呤阿糖甙)是一种纯核苷药物,可抑制某些DNA病毒的复制。有报导用该药治疗单纯疱疹病毒性脑炎患者,死亡率明显下降。按报导的用药量,毒性反应极小。由于给乙型肝炎病毒患者注射人体白细胞干扰素后Dane颗粒的标记—核心抗原(HBcAg)、血清DNA多聚酶和e抗原及乙型肝炎表面抗原(HBsAg)均下降了。因此作者对慢性活动性乙型肝炎患者用测定Dane颗粒的标记来估价该药的作用产生了兴趣。作者对两例活动性肝炎患者做了两个疗程的治疗。患者治疗前肝脏活检曾有异常,血清Dane颗粒DNA多聚酶的活力也高。用药方法:15毫克/公斤体重/日,共9—14天,疗程间歇期第一例为7周,第二例20天。治疗前后及治疗期间患者均未接受其他治疗。结果血清Dane颗粒相关的DNA多聚酶在第1例
Vidatridine (adenosine arabinoside) is a pure nucleoside drug that inhibits the replication of certain DNA viruses. There are reports of treatment of herpes simplex virus encephalitis in patients with this drug, the mortality decreased significantly. According to the reported dosage, minimal toxicity. Due to the reduction of Dna particles labeled with HBcAg, hepatitis E virus and e antigen as well as hepatitis B surface antigen (HBsAg) in patients with hepatitis B virus infection after human leukocyte interferon injection. Therefore, the authors of the active chronic hepatitis B patients with markers of Dane particles to assess the role of the drug has become interested. The author of two cases of active hepatitis patients did two courses of treatment. Liver biopsy patients had abnormalities before treatment, serum Dane DNA polymerase activity is also high. Medication: 15 mg / kg body weight / day, a total of 9-14 days, the first course of treatment interval is 7 weeks, the second 20 days. Before and after treatment and during treatment were not receiving other treatment. Results Serum Dane particles related to DNA polymerase in the first case