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ph~1是 CGL 的特征性异常。然而,人们发现有些病例虽然具有 CGL 的临床和血液学表现,却缺乏 Ph~1。前者通常称为 Ph~1阳性的 CGL[Ph~1(+)CGL],后者即所谓 Ph~1阴性的 CGL[Ph~1(-)CGL]。这一概念为 Kenis 等首先提出。旧文献中 Ph~(-)CGL 约占全部 CGL病例的10～36％。各家的报道不同,可能与所用的诊断标准不一致有关。近年来,随着深入的研究,人们越来越倾向于认为 Ph~1(-)CGL 是一组异质性疾病,其
ph ~ 1 is a characteristic abnormality of CGL. However, it has been found that although some cases have clinical and hematological manifestations of CGL, they lack Ph ~ 1. The former is usually called Ph ~ 1 positive CGL [Ph ~ 1 (+) CGL] and the latter is called Ph ~ 1 negative CGL [Ph ~ 1 (-) CGL]. This concept was first proposed by Kenis et al. The old Ph ~ (-) CGL accounted for about 10 ~ 36% of all CGL cases. Various reports vary and may not be consistent with the diagnostic criteria used. In recent years, with further research, people are more and more inclined to think that Ph ~ 1 (-) CGL is a heterogeneous group of diseases,