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对13种不同组成和结构的穿心莲注射液进行了解热、抗炎作用及毒性的比较研究。结果表明它们在结构和组成上各不相同,药理作用的强弱及性质上也有很大差异,一作者认为它们的二萜双环母核及五元内酯环基本结构可能是它们具有抗炎解热活性的基本结构,五元内酯环、双键、亚甲基以及羟基等的改变可不同程度地增减其作用强度及毒性,而以双键的增减及位置对活性的影响较为明显。
Thirteen kinds of different composition and structure of Andrographolide injection of antipyretics, anti-inflammatory effects and toxicity of the comparative study. The results show that they are different in structure and composition, the strength and nature of the pharmacological effects are also very different, one author believes that the basic structure of their diterpene bicyclic nucleus and five yuan lactone ring may be that they have anti-inflammatory solution The basic structure of thermal activity, five yuan lactone ring, double bond, methylene and hydroxyl changes can increase and decrease its intensity and toxicity to varying degrees, but with the double bond increase and decrease of the location of the activity of the more obvious .